Official websites use. Share sensitive information only on official, secure websites. In this study, underlying etiological causes and prognoses in children in follow-up due to neutropenia were analyzed to form a guide for physicians working in primary health care institutions. The medical records of pediatric patients who were followed up as an inpatients or outpatients due to neutropenia between October and October were reviewed retrospectively. A total of 94 patients were included in the study with a median age of 24 8—77 months. Of the total, 43 patients Fifty-five patients The most common focus of infection was the upper respiratory airway The 1 Month Escort Girl cause could not be identified in 23 No patient was diagnosed with congenital neutropenia. A total of 91 patients Neutropenia did not improve in 3 patients 3. One patient was lost due to infection. The most common etiological cause is infection. Drug use, nutritional deficiencies, and chronic benign neutropenia are less common causes of neutropenia. The clinical course is largely benign and the mortality rate is very low. Polymorphonuclear cells, known also as neutrophils, are the largest group of leukocytes in peripheral blood. They are produced from multipotent myeloid stem cells through a process of granulopoiesis in the bone marrow [ 1 ]. They are a part of the innate immunity 1 Month Escort Girl bacteria and fungi, and play an important role in initial defense of the 1 Month Escort Girl against the infection [ 2 ]. Certain populations e. Neutropenia can be classified as congenital or acquired. Congenital neutropenia is a heterogeneous hereditary group of disorders that are characterized by intermittent episodes or continuous severe or moderate neutropenia persisting for at least 3 months, and can develop at any stage of the proliferation and maturation phases of neutrophils, secondary to genetic causes. Although it occurs only rarely, congenital neutropenia is a significant condition that causes recurrent infections and has a chronic course, and exhibits autosomal recessive inheritance in the majority of cases [ 25 ]. Acquired neutropenia is more common than congenital neutropenia, with the most common causes being infections, drugs, and chronic benign neutropenia in infancy and childhood. It is believed that the majority of cases defined as chronic benign neutropenia in infancy and childhood represent an autoimmune neutropenia that is parallel to childhood idiopathic thrombocytopenic purpura [ 2 ]. Spontaneous remission is observed in almost all patients, and the median duration of neutropenia is 20 months [ 9 ]. The likelihood of spontaneous remission is higher in children younger than 9 months at the time of diagnosis, and this likelihood decreases with increasing age [ 2 ]. Apart from these, bone marrow involvement, nutritional causes, immunological disorders, metabolic disorders, autoimmune lymphoproliferative syndrome, and Evans syndrome are other causes of acquired neutropenia [ 25 ]. The present study determines the underlying etiological causes, clinical course, and prognosis in children followed up at our hospital due to neutropenia. The present study retrospectively reviewed the medical records of patients who were under follow-up as inpatients or outpatients at the pediatric hematology and oncology clinic between October and October Age, gender, blood count on admission, physical examination findings, diagnoses established after laboratory tests, recovery in neutrophil counts during follow-up, time of recovery, and changes in the disease course were garnered from the patient charts. Infections were diagnosed using anamnesis, physical examination, and clinical and laboratory findings. A throat culture was taken from patients with lower and upper respiratory tract infections. Gaita microscopy was studied for patients with gastroenteritis. For the diagnosis of lower respiratory tract infections, a radiological assessment was made in addition to cultures. No specimen was taken from the lower respiratory tract since our patients were at very young age. Previous blood counts were evaluated to determine whether neutropenia had a new onset or previously existed. It was assumed that neutropenia had newly developed in patients without a previously performed blood count. This study was approved by the Eskisehir Osmangazi University Non-Interventional Research Ethics Committee ethic approval no: 23 and was conducted in accordance with principles of Helsinki Declaration. Because there are various causes of childhood neutropenia, making the determination of the possible cause in a child is very difficult for pediatricians.
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